Abstract
The development of reliable method for detection of hypochlorite (ClO−) in vivo is of great importance to understand the precise roles of ClO− in a variety of pathological and physiological processes. Herein, three novel camphor-based fluorescence probes (2a-2c) for the ratiometric detection of ClO− were designed and synthesized, which exhibited both a distinct red shift of the fluorescence emission and a marked enhancement of the fluorescence intensity ratio in response to ClO−. The probes 2a-2c could selectively and sensitively detect ClO− with rapid response time, wide pH application range and low detection limit. The sensing mechanism was carefully confirmed by the ESI-MS, 1H NMR and DFT studies. In addition, the cell imaging experiments demonstrated that the probes 2a-2c could be successfully applied to imaging ClO− in living cells.
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