Abstract
Secondary metabolites obtained from marine-derived fungi are rich sources of drug candidates. Three new sesquiterpenoids, chermesiterpenoids A–C (1–3), along with four known alkaloids (4–7), were isolated and identified from the marine red algal-derived fungus Penicillium chermesinum EN-480. The structures of these new sesquiterpenoids were elucidated using detailed analysis of the NMR data and their relative configurations were elucidated using nuclear overhauser effect spectroscopy (NOESY) spectra as well as gauge-independent atomic orbital (GIAO) NMR shift calculations and DP4+ probability analysis. Their absolute configurations were determined using electronic circular dichroism (ECD) calculations and modified Mosher’s method. Compounds 2 and 3 exhibited potent activities against human and aquatic pathogenic bacteria and plant pathogenic fungi.
Highlights
Marine-derived fungi are rich sources of diverse and bioactive secondary metabolites [1,2].Among them, the species of the genus Penicillium play an important role and have increasingly attracted attention [3]
Our current research focuses on Penicillium chermesinum EN-480, a fungal strain isolated from the fresh tissue of the marine red alga Pterocladiella tenuis [4]
Meroterpenoids [4], cytotoxic metabolites [5], azaphilones [6], terphenyls [6], and plastatin [7] have been obtained from the species P. chermesinum
Summary
Marine-derived fungi are rich sources of diverse and bioactive secondary metabolites [1,2]. The species of the genus Penicillium play an important role and have increasingly attracted attention [3]. Our current research focuses on Penicillium chermesinum EN-480, a fungal strain isolated from the fresh tissue of the marine red alga Pterocladiella tenuis [4]. Meroterpenoids [4], cytotoxic metabolites [5], azaphilones [6], terphenyls [6], and plastatin [7] have been obtained from the species P. chermesinum. Some of them exhibited antibacterial [4] and enzyme inhibitory [6]. We obtained antimicrobial meroterpenoids from P. chermesinum
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