Abstract
Three new pyrrole alkaloids albifipyrrols A–C (1–3), were isolated from the endophytic fungus Albifimbria viridis collected from the Chinese medicinal plant. Their structures were elucidated by extensive NMR and HRESIMS spectrometric analyses. All compounds were evaluated for immunosuppressive activity. Fortunately, compound 2 exhibits certain inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC50 value 16.16 μM.Graphical
Highlights
1 Introduction The human immune system is a complex network of defensing against foreign invaders
Autoimmune diseases arise when the immune system fails to distinguish between self and non-self [1, 2]
The well-known anticancer drug paclitaxel can be produced from Pacific yew by the endophytic fungus Taxomyces andreance [17]
Summary
The human immune system is a complex network of defensing against foreign invaders. Autoimmune diseases arise when the immune system fails to distinguish between self and non-self [1, 2]. We obtained a pyrrole alkaloid with immunosuppressive activity from Albifimbria viridis. (calcd for 266.1157), which indicated that the molecular formula of compound 1 is C15H17NO2, with eight degrees of unsaturation.
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