Three New Megastigmane Glycosides from Hylomecon vernalis

Abstract

has been used as Chinese folk medicine for the treatment of arthritis, neuralgia, and eczema. 3 Previous phytochemical and pharmacological studies on this plant reported the isolation of several alkaloids and reported them to have antiinflammatory, antispasmodic, antimicrobial, and anti-tumoral activities. 3,4 Column chromatographic purification of the BuOH-soluble fraction of the MeOH extract of the aerial parts of H. vernalis led to the isolation of three new megastigmane glycosides (1-3), together with four known compounds (4-7). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectral analyses. The structures of the known compounds were identified to be (6R, 9R)-3-oxo-α-ionyl-9-O-α-L-rhamnopyranosyl