Abstract
Three new compounds of the malyngamide series, 6,8-di-O-acetylmalyngamide 2 (1), 6-O-acetylmalyngamide 2 (2), and N-demethyl-isomalyngamide I (3), were isolated from the marine cyanobacterium Moorea producens. Their structures were determined by spectroscopic analysis and chemical derivatization and degradation. These compounds stimulated glucose uptake in cultured L6 myotubes. In particular, 6,8-di-O-acetylmalyngamide 2 (1) showed potent activity and activated adenosine monophosphate-activated protein kinase (AMPK).
Highlights
The ocean covers more than 70% of the Earth’s surface and hosts huge biological and chemical diversity
The malyngamide series of natural products have been isolated from various marine filamentous cyanobacteria
As part of our ongoing effort to identify novel bioactive natural products, we have focused on the constituents of marine cyanobacteria and isolated odoamide [9,10] and odobromoamide [11]
Summary
The ocean covers more than 70% of the Earth’s surface and hosts huge biological and chemical diversity. Because marine environmental conditions are quite different from terrestrial ones, natural products from marine organisms have unique structures and biological activities. Bisebromoamide, isolated from Lyngbya sp., showed potent cytotoxicity against HeLa S3 cells [4]. The malyngamide series of natural products have been isolated from various marine filamentous cyanobacteria. A, the first compound of this group, was isolated from Lyngbya majuscule in 1979 [7]; since over 30 malyngamide analogs have been isolated [8]. As part of our ongoing effort to identify novel bioactive natural products, we have focused on the constituents of marine cyanobacteria and isolated odoamide [9,10] and odobromoamide [11]. We report the isolation, structure determination, and biological evaluation of these compounds.
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