Abstract
Three new lanostanoid triterpenes—ganotropic acid (1), 3β,7β,15α,24-tetra-hydroxy-11,23-dioxo-lanost-8-en-26-oic acid (2) and 3β,7β,15α,28-tetrahydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (3)—were isolated from the n-BuOH extract of the fruiting bodies of the mushroom Ganoderma tropicum. Their structures were elucidated by 1D and 2D NMR spectroscopy, as well as HR-EI-MS data.
Highlights
Ganoderma, the major genus in the family Ganodermataceae, are widely used to cure various chronic diseases such as hypertension, diabetes, hepatitis and cancers [1,2,3]
We describe the isolation, structural elucidation, and assay of AChE inhibitory activity of these new compounds
The main difference was a methylol group at δC 66.2 (C-28) in compound 3 instead of a methyl in 3β,7β,15β-trihydroxy-11,23-dioxolanost-8,16-dien-26-oic acid, indicating that compound 3 was derived from the latter with an additional hydroxyl group attached to C-28
Summary
The major genus in the family Ganodermataceae, are widely used to cure various chronic diseases such as hypertension, diabetes, hepatitis and cancers [1,2,3]. Ganoderma mushroom species found distributed in tropical areas of China. It is used as a health supplement and folk medicine alternative to Ganoderma lucidum and Ganoderma sinensis which are recorded in the Chinese Pharmacopeia to treat coronary heart disease and chronic hepatitis [11]. G. tropicum, among which 3β,7β,15β-trihydroxy-11,23-dioxolanost-8,16-dien-26-oic acid methyl ester showed AChE inhibitory activity [15,16]. In continuation of those studies, three new lanostanoids—ganotropic acid (1), 3β,7β,15α,24-tetrahydroxy-11,23-dioxolanost-8-en-26-oic acid (2). 3β,7β,15α,28-tetrahydroxy-11,23-dioxolanost-8,16-dien-26-oic acid (3) (Figure 1) have been obtained from the n-BuOH extract of the fruit bodies of this fungus. We describe the isolation, structural elucidation, and assay of AChE inhibitory activity of these new compounds
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