Abstract
Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC50 > 20 µM).Graphical
Highlights
Alkaloids are unique natural products denoted by the presence of a nitrogen atom as part of a heterocyclic ring, constituting a highly diverse group of compounds
Three new monoterpene indole alkaloids, 3a-hydroxymethyl-ibogamine (1), 3a-acetatemethoxyl-ibogamine (2), 16a-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae)
All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC50 [ 20 lM)
Summary
Alkaloids are unique natural products denoted by the presence of a nitrogen atom as part of a heterocyclic ring, constituting a highly diverse group of compounds. More than 12,000 different alkaloids, all of them plant-derived, are known To deal with this enormous diversity, these compounds are organized into dozens of structural related groups [1, 2]. (Apocynaceae) are widely distributed in tropical and subtropical regions of Africa, Asia, North America, Pacific Islands, South America, including five species in China This species are recognized as a rich source of MIAs [4], whereas the Iboga-type alkaloids ibogamine [5], voacangine [6], and coronaridine [7] are common in these species, they can be regarded as chemical markers for the genus. These compounds feature a nitrogen-containing seven-membered ring which is linked to the indole system. In the assessment of their bioactivities, the isolated alkaloids did not show significant activities against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC50 [ 20 lM)
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