Three New Derivatives and Others Constituents from the Roots and Twigs of Trilepisium madagascariense DC

Abstract

Three new compounds, trilepisflavene (1), trilepisdepsidone (2), and daturadiol stearate (3), together with nine known compounds, 2‐hydroxy‐4‐[(4‐hydroxy‐2‐methoxy‐6‐methylbenzoyl)oxy]‐6‐methylbenzoic acid (4), lichexanthone (5), naringenin (6), 3′,4′,5,7‐tetrahydroxyflavanone (7), 2‐hydroxybenzoic acid (8), methyl 2,4‐dihydroxy‐6‐methylbenzoate (9), β‐amyrin (10), eurothridiol palmitate (11), and β‐sitosterol (12), were isolated from the AcOEt extract of the twigs and the roots of Trilepisium madagascariense. Acetylation of eurothridiol palmitate was carried out and a new acetylated derivative (13) was obtained. The structures of the isolated and acetylated compounds were elucidated on the basis of spectroscopic analysis. Antimicrobial activity of all these compounds was evaluated using Mueller–Hinton broth (MHB) and Mueller–Hinton agar (MHA) method. Trilepisdepsidone, 2‐hydroxy‐4‐[(4‐hydroxy‐2‐methoxy‐6‐methylbenzoyl)oxy]‐6‐methylbenzoic acid, 3′,4′,5,7‐tetrahydroxyflavanone, and naringenin exhibited moderate to weak antimicrobial activity.