Abstract
AbstractThree new cytotoxic ent‐kaurane diterpenoids, (1α,7α,14β)‐1,7,14‐trihydroxy‐ent‐kaur‐16‐en‐15,18‐dione (1), (1α,7α,14β)‐1,7,14,18,20‐pentahydroxy‐ent‐kaur‐16‐en‐15‐one (2), and (3β,7α,14β)‐3,7,14‐tris(acetyloxy)‐ent‐kaur‐16‐en‐15‐one (3), were isolated from Isodon weisiensis C. Y. Wu. Their structures were elucidated by spectroscopic methods, including 2D‐NMR techniques, and the crystal structure of 1 was determined by single‐crystal X‐ray‐diffraction analysis. The chosen crystal of 1 was orthorhombic, space group P212121, and there were two molecules with little difference in bond length and bond angle in the least‐asymmetry unit. Compounds 1–3 showed significant cytotoxic activities against human‐cancer cell lines Bel‐7402 and HO‐8910.
Published Version
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