Three new bis-trinorcadalenes from Decaschistia intermedia Craib and their α-glucosidase inhibitory activities

Abstract

• Three new compounds were isolated from Decaschistia intermedia. • The structures were successfully determined by spectroscopic evidences. • Bistrinorcadintermes A–C showed moderate α -glucosidase inhibitory activities. Three new bis -trinorcadalenes, bistrinorcadintermes A–C ( 1 - 3 ) along with seven known compounds, parvifloral D ( 4 ), parvifloral E ( 5 ), parvifloral C ( 6 ), hymexelsin ( 7 ), scopoletin ( 8 ), scopolin ( 9 ), and hibiscolactone A ( 10 ) were isolated from the aerial parts and radix of Decaschistia intermedia Craib. Their chemical structures were determined based on spectroscopic methods, including 1D, 2D NMR, MS, and experimental CD spectra. All compounds were evaluated for their α -glucosidase inhibitory effects. Compounds 1 , 5 , and 8 showed moderate α -glucosidase inhibitory activities with IC 50 values of 45.6 ± 4.2, 43.7 ± 3.6, and 43.7 ± 3.6 μg/mL, respectively. Compounds 2 - 4 and 10 showed weak α -glucosidase inhibitory activities with IC 50 values ranging from 87.5 ± 6.3 to 219.8 ± 4.9 μg/mL.