Three new biphenyls from the twigs of Garcinia tetralata and their anti-tobacco mosaic virus activity

Abstract

Phytochemical investigations on the ethanol extract of the twigs of Garcinia tetralata resulted in the isolation of three new biphenyls, tetralatabiphenyls A–C (1–3), along with three known biphenyl derivatives (4–6). Structural elucidations of 1–3 were performed by spectroscopic methods such as 1D and 2D NMR spectra, in addition to high-resolution mass spectra. Compounds 1–6 were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 showed high anti-TMV activity with inhibition rate of 31.1%. Compounds 1, 2, and 4–6 also showed modest anti-TMV activities with inhibition rates in the range of 18.9–24.5%, respectively.