Three new abietane diterpenoids from Podocarpus fleuryi

Abstract

Three new abietane diterpenoids, fleuryinols A–C (1–3), together with fourteen known compounds, were isolated from the twigs and leaves of Podocarpus fleuryi. Their structures were established by spectroscopic analysis, including 1D- and 2D-NMR spectroscopic techniques. Compounds 1–8 were tested cytotoxic activity against five human cancer cell lines, HL-60, SMMC-772, A-549, MCF-7, and SW480, of which fleuryinol B (2) and 19-hydroxyferruginol (4) exhibited moderate cytotoxic activity against some cell lines.