Three Months Aerobic Training Cannot Modulate C-Terminal Telopeptide of Type 1 Collagen in Cigarette Smokers

Abstract

Background: Osteoporosis, as an important public health problem, is associated with cigarette smoking. Objectives: The present study aimed to evaluate the impact of 3 months supervised aerobic training program on C-terminal telopeptide of type 1 collagen (CTX) as a marker of bone resorption in male smokers. Methods: In this semi-experimental study, thirty-two sedentary adult male smokers (Winter 2016, Saveh, Iran) aged 42 ± 7 years were randomly assigned to exercise group (3 months aerobic training, 3 times/weekly at 60% - 75% of maximum heart rate, n = 16) or control group (no training, n = 16). Serum calcium, CTX and anthropometrical markers at before and after training were determined in exercise and control subjects. The statistical significance of the changes was evaluated by Student’s t-test. The changes less than 0.05 were considered statistically significant. Results: A significant decrease was observed in anthropometrical markers by aerobic training in the exercise group (P < 0.05). No significant changes were observed for serum calcium (P = 0.126) and CTX (P = 0.835) after aerobic intervention compared with baseline levels. No significant changes were observed in all variables in the control group (P ≥ 0.05). Conclusions: These data suggest that aerobic training with mentioned details cannot improve bone resorption with emphasis on CTX in male smokers. To achieve a better conclusion, it is necessary to assess the indicative markers of both bone resorption and formation in response to exercise.