Abstract
In 1956, the anti‐I antibody was first described in connection with a cold hemolytic anemia. Since that time, healthy individuals have been found with the anti‐I antibody and the phenotype i. The anti‐I antibody reacts best at 4 C. and weakly or not at all with cord blood and erythrocytes of known phenotype i. The I antigen is unstable with increasing age of the cell. Survival study with I incompatible erythrocytes labeled with Cr51 is reported for the first time and shows a T1/2 of 6.5 days.The identification of the anti‐I antibody in this patient and subsequent typing of his family has supplied three names for the rare donor file. A complete family study would be of interest and could possibly further establish evidence of genetic control of the Ii antigens.
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