Three Lymphadenectomy Strategies in Endometrial Carcinoma: Analysis of Long-Term Outcomes

Abstract

<h3>Study Objective</h3> Sentinel node mapping (SNM) has replaced lymphadenectomy for staging surgery in apparent early-stage endometrial cancer (EC). Here, we evaluated the long-term survival of three different approaches of nodal assessment. <h3>Design</h3> This is a multi-institutional retrospective study evaluating long-term outcomes (at least 3 years of follow-up) of EC patients having nodal assessment between 2006 and 2016. In order to reduce possible confounding factors, we applied a propensity-matched algorithm. <h3>Setting</h3> Referral centers. <h3>Patients or Participants</h3> Consecutive patients with EC undergoing surgical staging. <h3>Interventions</h3> Surgical staging including SNM and/or lymphadenectomy. <h3>Measurements and Main Results</h3> Charts of 1,338 patients were evaluated: 398 (29.7%), 174 (13.1%), 187 (13.9%), and 579 (43.3%) no retroperitoneal staging, SNM, SNM followed by backup lymphadenectomy and lymphadenectomy, respectively. Applying a propensity score matching algorithm (1:1:2) we selected 500 patients: 125 SNM vs. 125 SNM plus backup lymphadenectomy vs. 250 lymphadenectomies. Baseline characteristics of the study population were similar between groups. The prevalence of nodal disease was 14%, 16%, and 12% in patients having SNM, SNM followed by backup lymphadenectomy and lymphadenectomy, respectively. Overall, 19 (7.6%) patients were diagnosed with low volume nodal disease. The mean (SD) follow-up time was 62 (±11) months. The survival analysis comparing the three techniques did not show statistical differences in terms of disease-free (p=0.750) and overall survival (p=0.899). Similarly, the type of nodal assessment did not impact survival outcomes after stratification on the basis of uterine risk factors (p>0.2). <h3>Conclusion</h3> Our study highlighted that SNM provides similar long-term oncologic outcomes than lymphadenectomy. Randomized controlled trials are needed to corroborate the value of SNM in EC.