Three Japanese adult cases of brain lesions with anti‐myelin oligodendrocyte glycoprotein antibodies lacking optic neuritis and myelitis

Abstract

AbstractBackgroundAnti‐myelin oligodendrocyte glycoprotein antibodies (MOG‐Ab) are positive in some patients with neuromyelitis optica/neuromyelitis optica spectrum disorders; however, their clinical diversity remains unclear.Case presentationWe encountered three anti‐MOG‐Ab‐positive Japanese adult patients with brain lesions, but lacking optic neuritis and myelitis. Magnetic resonance imaging detected lesions in the cerebral gray and white matter, brainstem, and cerebellum, and 18‐fluorodeoxyglucose positron emission tomography imaging showed normal or decreased uptake in acute lesions.ConclusionsPatients with anti‐MOG‐Ab might present with brain lesions only, and lack optic neuritis and myelitis. The anti‐MOG‐Ab titer needs to be measured in inflammatory diseases that affect the central nervous system, including atypical multiple sclerosis and autoimmune meningoencephalitis.