Abstract
Background: Heavy and prolonged opium dependence is a progressing problem in the East. For the treatment of opium dependence, buprenorphine can be prescribed less frequently than daily due to its long half-life.Objective: To administered three high doses buprenorphine instead of daily use to reduce probability of buprenorphine dependence.Results: The prescription of three high doses of 32, 96 and 72 mg buprenorphine was tolerated conveniently. Administration of high doses of buprenorphine completely improved opium withdrawal symptoms.Discussion: The current work indicated that few high doses of buprenorphine, could be adequate and satisfactory for the improvement of heavy and prolonged opium dependence.Conclusions: We came to this result that administration of high dose buprenorphine looks to be convenient, acceptable and tolerable. More research studies should be of interest as high buprenorphine doses are getting more general clinically. We concluded that three doses of 32, 72 and 96 mg buprenorphine, could be adequate for the improvement of severe opium use disorder.
Highlights
Usage of opium has a long history of remedy intentions in many parts of the East especially Asia[1-3]
We examined three high doses of buprenorphine for the management of chronic opium dependence
This work demonstrated that three high doses of buprenorphine (32, 72 and 96 mg) could be adequate for opium withdrawal symptoms treatment
Summary
Usage of opium has a long history of remedy intentions in many parts of the East especially Asia[1-3]. Mainly buprenorphine has been under extensive research for the treatment of opioid use disorders[4]. Probing for the treatment of opium addiction, contrasting methadone with buprenorphine, disclosed that buprenorphine is more positive than methadone[5-7]. Buprenorphine, a medication with mixed agonist-antagonist characteristics, has been beneath rating as a potential detoxification drug for the management of opioids addiction. Evaluations have distinguished buprenorphine as an agonist of mu receptor, and as a strong K-receptor antagonist[9-12]. Buprenorphine has less intrinsic activity at preceptors comparing to full agonists[13-15]. Buprenorphine elicit typical long duration effects of mu opioid agonist, including analgesia, euphoria, pupillary constriction and sedation. A ceiling on the buprenorphine respiratory depressant and euphoric effects would produce more safety in clinical practice.
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