Abstract
BackgroundThere is currently no information on how different mandibular segments are affected by juvenile idiopathic arthritis. The aim of this paper is to assess volumetric differences of different mandibular segments in subjects with unilateral and bilateral JIA and to compare them with non-JIA control volumes.Materials and methodsForty subjects with unilateral TMJ involvement and 48 with bilateral TMJ involvement were selected for the case group and 45 subjects with no known rheumatic comorbidities for the control group. The mandible of each subject was divided according to a validated method into different paired volumes (hemimandible, condyle, ramus and hemibody).ResultsThe ANOVA test revealed a statistically significant difference in all the groups for condylar and ramus volumes, and the pairwise comparison evidenced a statistically significant higher condylar and ramus volume in the control group (1444.47 mm3; 5715.44 mm3) than in the affected side in the unilateral JIA group (929.46 mm3; 4776.31 mm3) and the bilateral JIA group (1068.54 mm3; 5715.44 mm3). Moreover, there was also a higher condylar volume in the unaffected side in the unilateral JIA group (1419.39 mm3; 5566.24 mm3) than in the bilateral JIA group and the affected side in the unilateral JIA group.ConclusionsThe affected side of unilateral JIA patients showed statistically significant lower volumes in the hemimandible, in the condyle and in the ramus. The largest total mandibular volume was observed in the control group, followed by the unilateral JIA group and, lastly, by the bilateral JIA group.
Highlights
There is currently no information on how different mandibular segments are affected by juvenile idiopathic arthritis
The largest total mandibular volume was observed in the control group, followed by the unilateral Juvenile idiopathic arthritis (JIA) group and, lastly, by the bilateral JIA group
The non-JIA group and the unaffected side of unilateral JIA patients had bigger condyles than the bilateral JIA group and the affected side of unilateral JIA subjects, confirming the findings reported in the literature
Summary
There is currently no information on how different mandibular segments are affected by juvenile idiopathic arthritis. Juvenile idiopathic arthritis (JIA) involves a group of conditions with joint inflammation (arthritis) with a female-to-male ratio of 3–6:1 [1] It is the most common childhood rheumatic disease affecting children in Europe. The most active growth center for the mandible is located on the condylar head joint surface and, is often damaged by this rheumatic condition leading to an altered, asymmetrical growth [9, 10] The reason for this growth impairment is poorly understood, and there are several factors that might contribute to this, such as the presence of high levels of proinflammatory cytokines and chronic use of corticosteroids (CS) to control JIA, malnutrition and immobilization [8]. The mandibular ramus of affected condyles is shortened and often asymmetrical [11,12,13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
