Abstract

Diffraction patterns of a single myocardial thin filament and its Mg-paracrystals from normal myocardium and in cardiac insufficiency caused by toxic allergic myocarditis were presented, and three-dimensional reconstruction of normal and pathological filaments was carried out. It was shown that in a rigor solution pathological actin protomers are elongated, while normal filaments are kidney-shaped. It is concluded that changes in the thin myocardial filament helix parameters in heart failure caused by toxic allergic myocarditis are due to the loss of conformational mobility of native actin filaments.

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