Abstract
The archaeal/eukaryotic tyrosyl tRNA synthetase (TyrRS)-tRNA(Tyr) pairs do not cross-react with their prokaryotic counterparts. Recently, crystal structure analyses of prokaryotic and archaeal TyrRSs complexed with their cognate tRNA(Tyr) have been reported, however, no structure is available for eukaryotic TyrRS complexed with its cognate tRNA(Tyr). Here we report the crystal structure of yeast Tyrosyl-tRNA synthetase (yTyrRS) complexed with its cognate tRNA(Tyr) and Tyr-AMP analog.
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