Three-dimensional orientation of the eye rotation axis during the Purkinje sensation

Abstract

The otolith-semicircular canal interaction during postrotatory nystagmus was studied in six normal human subjects by applying fast, short-lasting, passive head and body tilts (90° in the roll of pitch plane) 2 s after sudden stop from a constant velocity rotation (100°/s) about the earth-vertical axis in yaw. Eye movements were measured with 3-D magnetic search coils. Following the head tilt, activity in the semicircular canal primary afferents continues to reflect the postrotatory angular velocity vector in head-centered coordinates, whereas otolith primary afferents signal a different orientation of the head relative to gravity. Pitch (roll) tilts away from upright during postrotatory nystagmus after yaw rotation elicited a transient vertical (torsional) VOR. Despite the change in head orientation relative to gravity, postrotatory eye velocity decayed closely along the axis of semicircular canal stimulation (horizontal in head coordinates). These results suggest that postrotary nystagmus is largely organized in head-centered rather than gravity-centered coordinates in humans as suggested by the Purkinje-sensation.