Three Dimensional Normal Tissue Dose Reconstruction of Historical Hodgkin's Lymphoma Patients for Correlation with Late Toxicity

Abstract

Biologically-based models that utilize 3D radiation dosimetry data to estimate the risk of late effects could have significant utility for planning radiotherapy (RT) in young patients. A major challenge arises from having only 2D treatment planning data for patients with long-term follow-up. We previously described a method of reconstructing 3D lung and heart volumes using 2D treatment planning data. Herein, we evaluate the accuracy of 3D normal tissue dosimetry derived from reconstructed 2D treatment plans of recently- and historically-treated Hodgkin's Lymphoma (HL) patients.