Three-dimensional infrared scanning: an enhanced approach for spatial registration of probes for neuroimaging.

Abstract

Accurate spatial registration of probes (e.g., optodes and electrodes) for measurement of brain activity is a crucial aspect in many neuroimaging modalities. It may increase measurement precision and enable the transition from channel-based calculations to volumetric representations. This technical note evaluates the efficacy of a commercially available infrared three-dimensional (3D) scanner under actual experimental (or clinical) conditions and provides guidelines for its use. We registered probe positions using an infrared 3D scanner and validated them against magnetic resonance imaging (MRI) scans on five volunteer participants. Our analysis showed that with standard cap fixation, the average Euclidean distance of probe position among subjects could reach up to 43mm, with an average distance of 15.25mm [standard deviation (SD) = 8.0]. By contrast, the average distance between the infrared 3D scanner and the MRI-acquired positions was 5.69mm (SD = 1.73), while the average difference between consecutive infrared 3D scans was 3.43mm (SD = 1.62). The inter-optode distance, which was fixed at 30mm, was measured as 29.28mm (SD = 1.12) on the MRI and 29.43mm (SD = 1.96) on infrared 3D scans. Our results demonstrate the high accuracy and reproducibility of the proposed spatial registration method, making it suitable for both functional near-infrared spectroscopy and electroencephalogram studies. The 3D infrared scanning technique for spatial registration of probes provides economic efficiency, simplicity, practicality, repeatability, and high accuracy, with potential benefits for a range of neuroimaging applications. We provide practical guidance on anonymization, labeling, and post-processing of acquired scans.