Abstract
Light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). However, the irregular morphologies of lesions complicate lesion segmentation and light irradiance adjustment. Therefore, this study developed an illumination demo system comprising a camera, a digital projector, and a computing unit to solve these problems. A three-dimensional model of a lesion was reconstructed using the developed system. Hierarchical segmentation was achieved with the superpixel algorithm. The expected light dosimetry on the targeted lesion was achieved with the proposed illumination procedure. Accurate control and optimization of light delivery can improve the efficacy of PDT.
Highlights
Photodynamic therapy (PDT) is a widely used dermatological treatment based on photodynamic reactions
This study proposes a three-step treatment procedure for PDT
Projectors are often based on lamps, laser and light-emitting diodes (LEDs) light engines are used in high-brightness projectors
Summary
Photodynamic therapy (PDT) is a widely used dermatological treatment based on photodynamic reactions. Common adverse effects of PDT include various degrees of pain and a burning sensation. Pain level increases with irradiance; the exact pain mechanism remains unclear.[10] Significant advances in light dosimetry studies of PDT have been obtained for in vivo propagation models, which correlate incident irradiance and physiological outcomes in biological materials.[11,12] light dosimetry is hardly controllable in vivo because of irregularly shaped lesions, segmentation difficulty in normal areas, the patient’s movement during the treatment, and so on
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