Abstract
BackgroundThe role of injectable platelet rich fibrin (i-PRF) in orthodontic treatment has not been investigated with focus on its effect on dental and bony periodontal elements.ObjectiveTo evaluate the efficacy of i-PRF in bone preservation and prevention of root resorption.MethodsA randomized split-mouth controlled trial included 21 patients aged 16–28 years (20.85 ± 3.85), who were treated for Class II malocclusion with the extraction of the maxillary first premolars. Right and left sides were randomly allocated to either experimental treated with i-PRF or control sides. After the leveling and alignment phase, the canines were retracted with 150gm forces. The i-PRF was prepared from the blood of each patient following a precise protocol, then injected immediately before canine retraction on the buccal and palatal aspects of the extraction sites. Localized maxillary cone beam computed tomography scans were taken before and after canine retraction to measure alveolar bone height and thickness and canine root length (indicative of root resorption), and the presence of dehiscence and fenestration. Paired sample t-tests and Wilcoxon signed rank tests were used to compare the changes between groups.ResultsNo statistically significant differences in bone height, bone thickness were found between sides and between pre- and post-retraction period. However, root length was reduced post retraction but did not differ between sides. In both groups, postoperative dehiscence was observed buccally and palatally and fenestrations were recorded on only the buccal aspect.ConclusionsI-PRF did not affect bone quality during canine retraction or prevent canine root resorption. I-PRF did not reduce the prevalence of dehiscence and fenestration.Trial registration ClinicalTrials.gov (identifier number: NCT 03399760. 16/01/2018).
Highlights
Orthodontists have committed various technologies to accelerate tooth movement for the twin purpose of avoiding the side effects of protracted intervention and Zeitounlouian et al BMC Oral Health (2021) 21:92 meeting the patients’ aspiration for shorter treatment [1]
I-PRF did not reduce the prevalence of dehiscence and fenestration
Biomaterials like platelet rich plasma (PRP) and fibrin (PRF) have been advocated as promising alternatives to accelerate orthodontic tooth movement (OTM) with less risk of bone and periodontal loss [12,13,14,15,16] because of their high contents of growth factors that play an important role in angiogenesis, wound healing and bone regeneration [17]
Summary
Orthodontists have committed various technologies to accelerate tooth movement for the twin purpose of avoiding the side effects of protracted intervention and Zeitounlouian et al BMC Oral Health (2021) 21:92 meeting the patients’ aspiration for shorter treatment [1]. Adequate alveolar bone volume and root length are prerequisite conditions for successful orthodontic tooth movement (OTM) and post treatment stability [6]. Biomaterials like platelet rich plasma (PRP) and fibrin (PRF) have been advocated as promising alternatives to accelerate OTM with less risk of bone and periodontal loss [12,13,14,15,16] because of their high contents of growth factors that play an important role in angiogenesis, wound healing and bone regeneration [17]. The role of injectable platelet rich fibrin (i-PRF) in orthodontic treatment has not been investigated with focus on its effect on dental and bony periodontal elements
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