Abstract
BackgroundThe structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility. The aim of the study was to demonstrate that the imaging technique is an appropriate method for micron imaging of the gastric structures.MethodsThe stomachs of 4-, 6- and 12-week-old rats were removed and cleaned. XILPCI has 1000 times greater soft tissue contrast than that of X-ray traditional absorption radiography. The projection images of the rats stomachs were recorded by an XILPCI charge coupled device (CCD) at 9-μm image resolution.ResultsThe X-ray in-line phase-contrast images of the different stages of rats’ gastric specimens clearly showed the gastric architectures and the details of the gastro-duodenal region. 3-dimensional (3D) stomach anatomical structure images were reconstruction.ConclusionThe reconstructed gastric 3D images can clearly display the internal structure of the stomach. XILPCI may be a useful method for medical research in the future.
Highlights
The structural changes of gastric mucosa are considered as an important window of early gastric lesions
X-ray in-line phase-contrast imaging (XILPCI), using the X-ray phasechange after an X-ray passes through objects, has emerged as an imaging method and used to acquire micrometer level images of soft tissues
On XILPCI images, a 4-week-old image shows a uniform grey level, which indicates that the wall of the 4-week-old gastric corpus is as thick as the gastric fundus
Summary
The structural changes of gastric mucosa are considered as an important window of early gastric lesions. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility. The aim of the study was to demonstrate that the imaging technique is an appropriate method for micron imaging of the gastric structures. The stomach is an important organ in the alimentary tract. The imaging observation of its development has not been realized yet. This mainly employs gastroscopy which could obtain the image at a millimeter level. X-ray in-line phase-contrast imaging (XILPCI), using the X-ray phasechange after an X-ray passes through objects, has emerged as an imaging method and used to acquire micrometer level images of soft tissues.
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