Abstract
This study used a mouse model of hyperuricemia (HUA) to compare the effects of three phenols derived from pickled radish: 2,6-dihydroxyacetophenone (DHAP), 4-hydroxyphenylethanol (4-HPEA), and 4-hydroxybenzaldehyde (HBA) on uric acid (UA) levels and related biomarkers, as well as their association with gut microbiota. Serum UA levels and xanthine oxidase (XOD) activity were significantly lower after HBA treatment compared to other phenol-treated groups (p < 0.05). DHAP and HBA significantly reduced creatinine (CRE) and blood urea nitrogen (BUN) levels, ameliorating renal dysfunction (p < 0.05). 16S rRNA results showed that DHAP and 4-HPEA increased the relative abundance of Lactobacillus (p < 0.05). HBA demonstrated the strongest UA-lowering effect among the phenols, attributed to its renal function improvement and gut microbiota regulation.
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