Three-component synthesis of functionalized 4,5,6,7-tetrahydroindole derivatives

Abstract

Multicomponent condensations offer quite efficient and convenient methods for the synthesis of polynuclear nitrogen-containing heterocycles which can thus be obtained in one step from accessible starting compounds. Three-component condensations involving methylene-active compounds (1,3-diketones, barbituric acid), their nitrogen equivalents (enamino ketones, 6-aminouracil), and aromatic aldehydes have been studied most thoroughly. In particular, oxo derivatives of pyrido[2,3-d]pyrimidine [1] and pyrimido[4,5-b]quinoline [2–5] have been synthesized in this way.