Abstract
An efficient one-pot procedure has been developed for the synthesis of bridged 1,3,5-triazinanes, unexplored classes of heterocyclic polydentate scaffolds. By means of a pseudo five-component reaction between primary diamines (ethylenediamine, 1,3-propylenediamine, 1,4-butylenediamine), sulfonamides, and three equivalents of paraformaldehyde, a broad series of 1,3,5-triazabicyco[3.2.1]octanes, 1,3,5-triazabicyco[3.3.1]nonanes and 1,6,8-triazobicyclo[4.3.1]decanes were prepared. Boiling chloroform and an additive of Mg(ClO4)2 were shown to be the most efficient conditions for the condensation. Putrescine is probably the longest diamine which can be involved in this protocol. It was demonstrated that сadaverine was unsuitable for preparation of corresponding 1,7,9-triazabicyclo[5.3.1]undecanes. The structure of all classes of the obtained azabicycles was elucidated by XRD analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
