Abstract
A direct single-pot three-component procedure for synthesizing bio-active hydrazinyl thiazole derivatives has been demonstrated. The reaction involves substituted 2-Bromoacetophenones, carboxaldehydes, and thiosemicarbazide to form the hydrazinyl thiazole scaffolds via a simple condensation reaction followed by intramolecular cyclization with p-TSA as a catalyst at room temperature. The ease of product separation, lack of column chromatographic purification, and use of readily available starting materials result in an efficient approach for organic synthesis.
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