Abstract
A suitable one-pot sequential three-component synthesis of a series of new spiro[indoline-pyrrolidine] derivatives is described. Reactions proceeded through a 1,3-dipolar cycloaddition between azomethine ylides, generated in situ from the condensation of isatins with sarcosine, and trans-1,2-dibenzoylethylene as dipolarophile under conventional heating. This protocol provides a mild reaction condition with operational simplicity, affording high regioselectivity and stereoselectivity, enabling to assemble a complex structural entity in a single step in good to excellent yields. The regio- and stereochemical outcome of this cycloaddition reaction was ascertained by spectroscopic analysis. Also, DFT quantum chemical calculation was used to establish the geometries and electronic structures of the obtained compounds.
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