Abstract
Mechanical properties of individual muscle fibers from rabbit psoas were probed by applying sinusoidal length changes at one end of the fiber and measuring the resulting force at the other end. At frequencies above 1 Hz, this oscillation resulted in a history-dependent reduction in muscle fiber stiffness in activated muscle fibers. Such a reduction in muscle stiffness in response to force is referred to as thixotropy. Perturbing the actin-myosin interaction by treatment with EDTA and blebbistatin caused this effect to disappear, suggesting that this thixotropy results from cross-bridge interactions. At frequencies less than 1 Hz, oscillation resulted in a history-dependent increase in muscle fiber stiffness in activated fibers. Disruption of actin-myosin interactions has no effect on this negative thixotropy, suggesting a different mechanism is at play.
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