Abstract

Whipple's disease is a rare inflammatory disorder caused by infection of different organ systems with Tropheryma whipplei. In the gastrointestinal tract, jejunal infection with T whipplei causes diarrhea or steatorrhea with weight loss. Treatment with a combination of doxycycline, hydroxychloroquine, and sulfamethoxazole or sulfadiazine is usually recommended, but prospective data assessing the efficacy of these antibiotics are lacking. Moreover, retrospective case series report failure rates of up to 30% using these antibiotic regimens.

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