Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain, inflammation, and fever, but are associated with complications of peptic ulcer formation, perforation, and bleeding, mediated through the inhibition of cyclooxygenase-1 (COX-1). Several controlled studies have shown that the use of selective inhibitors of COX-2 (COXIBs) is associated with less peptic ulcer and bleeding complications than the use of nonselective NSAIDs. Whereas the increased risk of gastrointestinal complications with nonselective NSAIDs has been well demonstrated in epidemiologic studies, similar data are lacking for selective COXIBs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
