Abstract
In a recent paper in AIDS Chi et al. reported a secondary analysis of data from HIVNET 024 that addressed the importance of timing of maternal and infant nevirapine (NVP) dosing in preventing mother-to-child transmission (MTCT) of HIV. Their analysis extended the documentation of the marked success of this strategy in preventing intrapartum/early postnatal transmission of HIV in low-resource areas. Yet despite these gains in some areas of Zambia one third of HIV infected pregnant women did not take single-dose NVP during labour. Three reports of MTCT in 2005 at the Twelfth Conference on Retroviruses and Opportunistic Infections in Boston (DITRAME+ DREAM and MASHI) documented a further and dramatic reduction in vertical transmission of HIV to < 5%. (excerpt)
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