Abstract
How the antidiuretic hormone regulates water metabolism has not been completely elucidated and hence any further light thrown on this question is always of interest. In 1942 we observed that in two cases of diabetes insipidus the administration of pitressin suppressed the sensation of thirst, even without the ingestion of water (Pasqualini & Avogadro). This effect of pitressin was referred to, as the antidipsetic action of this hormone (Pasqualini, 1956). Since then it has been possible to study this property of pitressin in 12 cases of diabetes insipidus. The results of such an investigation are rather difficult to assess, so that in only 12 out of a total of more than 50 cases of diabetes insipidus was it possible to obtain exact information. The patients ranged from 3 to 40 years of age (Table 1) and the disease had started from 6 months to 28 years previously.
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