Abstract
Strong evidence implicates maternal phthalate exposure during pregnancy in contributing to adverse birth outcomes. Recent research suggests these effects might be mediated through the improper regulation of DNA methylation in offspring tissue. In this study, we examined associations between prenatal phthalate exposure and DNA methylation in human placenta. We recruited 181 mother-newborn pairs (80 fetal growth restriction newborns, 101 normal newborns) in Wenzhou, China and measured third trimester urinary phthalate metabolite concentrations and placental DNA methylation levels of IGF2 and AHRR. We found urinary concentrations of mono (2-ethyl-5- hydroxyhexyl) phthalate (MEHHP), and mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) were significantly inversely associated with placental IGF2 DNA methylation. The associations were much more evident in fetal growth restriction (FGR) newborns than those in normal newborns. These findings suggest that changes in placental DNA methylation might be part of the underlying biological pathway between prenatal phthalate exposure and adverse fetal growth.
Highlights
Strong evidence implicates maternal phthalate exposure during pregnancy in contributing to adverse birth outcomes
Analysis of variance showed that urinary concentrations of mono (2-ethyl-5- hydroxyhexyl) phthalate (MEHHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and summed as total DEHP (SumDEHP) were significant higher in fetal growth restriction (FGR) cases than those in normal controls
Since prenatal phthalate exposure is negatively associated with fetal growth[3,4], it is DNA methylation
Summary
Strong evidence implicates maternal phthalate exposure during pregnancy in contributing to adverse birth outcomes Recent research suggests these effects might be mediated through the improper regulation of DNA methylation in offspring tissue. The associations were much more evident in fetal growth restriction (FGR) newborns than those in normal newborns These findings suggest that changes in placental DNA methylation might be part of the underlying biological pathway between prenatal phthalate exposure and adverse fetal growth. In human study, only a few studies reported DNA methylation alterations in relation to phthalate exposure[8,22,23] In this present study, we measured DNA methylation of 2 growth-related genes (IGF2 and AHRR) in placentas from fetal growth restriction (FGR) newborns and normal newborns. We hypothesize that changes in placental DNA methylation is part of the underlying biological pathway between prenatal phthalate exposure and adverse fetal growth
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
