Abstract
The correlation among the frequencies of appearance of G and C bases at the first, second and third positions of codons is examined. It is found that the redundancy at the wobbling third base is utilized to counter-balance the local (G + C)-content variation due to the first and second bases of codons, so that a homogeneous (G + C)-content is provided to each individual gene. We speculate that this levelling tendency of (G + C)-content comes from the functional constraint to achieve a uniform double-helix stability in a gene.
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