Abstract
BackgroundPiroxicam (PX) is a nonsteroidal anti-inflammatory drug of the oxicam category that has been known worth as a chemopreventative, anti-tumor agent, for acute and chronic musculoskeletal. To the best of our knowledge, no paper has been published until now reporting the simultaneous electrocatalytic detection of isoprenaline and PX by using any type of modified electrodes.MethodsThe glassy carbon electrode modified with multiwalled carbon nanotubes chemically modified with (z)-1-(3,4-dihydroxybenzylidene)-2-methylthiosemicarbazide (DBT–CNT/GCE). The electrocatalytic behavior of analytes was examined using cyclic voltammetry (CV), chronoamperometry, and differential pulse voltammetry (DPV) on the modified electrode.ResultsIn order to determine kinetic parameters such as the anodic transfer coefficient (α = 0.47) and the electron transfer rate constant between the nanocomposite and glassy carbon electrode (ks/s = 0.51), cyclic voltammetry was applied. The results represented a linear relationship versus isoprenaline concentrations in the wide range of 0.5–1500.0 μM and a detection limit of 0.35 μM. Furthermore, DPV was applied successfully for the simultaneous determination of isoprenaline and piroxicam.ConclusionsThis proposed sensor has been successfully applied to determine the IP and PX in blood serum human, which demonstrates that it has excellent potential application for detection of different concentrations of IP and PX.
Highlights
Piroxicam (PX) is a nonsteroidal anti-inflammatory drug of the oxicam category that has been known worth as a chemopreventative, anti-tumor agent, for acute and chronic musculoskeletal
Electrochemical properties of DBT–carbon nanotubes (CNTs)/Glassy carbon electrode (GCE) The electrochemical behavior of the DBT–CNT/GC modified electrode was investigated by cyclic voltammetry at different scan rates in a buffered solution
Chemically functionalized carbon nanotubes have presented a significant role in the investigation and progression of nanotube-based materials and systems
Summary
Piroxicam (PX) is a nonsteroidal anti-inflammatory drug of the oxicam category that has been known worth as a chemopreventative, anti-tumor agent, for acute and chronic musculoskeletal. The newly developed chemical methods for chemical functionalization of carbon nanotubes, specially modification techniques, permit variation of the electronic properties of the tubes, as well as chemical surface properties. These functionalized carbon nanotubes have provided an extensive range of new applications such as nanostructured electronic devices, chemical. It is important to know that carbon nanotubes (CNTs) usually are agglomerates of several hundred micrometers in size (Wang et al 2003). These entanglements cause nanotubes to disperse in polymer matrix difficultly.
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