Thiophene-based macrocycles via the Suzuki–Miyaura cross coupling reaction

Abstract

Suzuki–Miyaura cross coupling reaction was used for access to new macrocycles exhibiting oligoethyleneoxide bridges and embedding bithiophene, terthiophene or 3,7-bis(thiophen-2-yl)-N-ethyl-10H-phenothiazine units. The synthesis was performed under various reaction conditions and different coupling types in order to establish the correlation between yields and employed solvents and bases. The structure of the compounds was supported by single crystal X-ray diffractometry, NMR, and MS experiments.