Thiol-disulphide homoeostasis as a novel oxidative stress biomarker in lung tuberculosis patient.

Abstract

To compare a novel oxidative stress biomarker dynamic thiol/disulphide homoeostasis between patients with lung tuberculosis and healthy controls. Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulphide was measured with a new automated spectrometric method developed and results were compared statistically. We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulphide/native thiol and disulphide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulphide levels were higher in the control group than in the patient group. Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.