Abstract
Stem cell therapies are believed to hold promises for a wide range of neurodegenerative diseases but suffer from the harsh local microenvironment. Here we develop a gellan gum (GG)-based hydrogel that serves as a 3D platform for neural stem cell culture and sustained release of peptide to promote transplant stem cell survival and differentiation. The thiolated GG (TGG) maintains the temperature-sensitive gelation properties of GG while providing binding sites to the peptide for sustained release. TGG hydrogels combined with laminin promote survival of encapsulated human neural stem cells. This TGG hydrogel can serve as a therapeutic adjunct in a stem cell therapy through selective control of stem cell survival and differentiation.
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