Abstract

In this paper we report an easy and low‐cost way to prepare a hydrophobic substrate for drop coating deposition Raman (DCDR) spectroscopy. This substrate is formed by a thiol‐modified Au‐coated glass and provides the Raman spectra with the same quality as the commercial Teflon‐coated stainless steel substrate (SpectRIM™, Tienta Sciences, Inc.) for model molecular systems – albumin solution and liposome suspension. Gold layer, similarly to polished steel in the commercial substrate, served as a highly refractive layer strongly increasing the Raman signal. The main advantage of introduced substrate is that it is simple and a low‐cost preparation easily manageable in every standard laboratory. Thus, it represents a promising alternative to commercial Teflon‐coated stainless steel substrate. Copyright © 2016 John Wiley & Sons, Ltd.

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