Abstract
The hydrogel thiopropyl-sepharose 6B was used as a model matrix system to bind the natural cytotoxic sesquiterpene lactones grosheimin 1 and deacylcynaropicrin 2. The hydrogel thio groups were bonded to the lactone exomethylene groups and the release of the lactones from the polymer was studied. Since it is thought that cancer cells have a higher oxidative potential than normal cells, the release was carried out through an oxidative cleavage. Different concentrations of hydrogen peroxide solutions were added to the lactone-polymer conjugates, thus, imitating in vivo conditions. The results obtained showed that both the rate and amount of grosheimin and deacylcynaropicrin release depend linearly on the H2O2 concentration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
