Abstract
SummaryBackgroundThe purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemia-modified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and non-insulin-resistant groups in comparison with an overweight group.MethodsWe compared plasma thiol/disulphide, IMA levels, and ferroxidase activity between the study groups. We analyzed plasma thiol/disulphide homeostasis with a newly developed automated measurement method; IMA with Albumin Cobalt Binding Test and ferroxidase (ceruloplasmin) levels with an automated, colourimetric method.ResultsThere were no significant differences between insulin-resistant and non-insulin-resistant women with obesity in terms of plasma native thiol, total thiol, disulphide, disulphide/native thiol ratio, disulphide/total thiol or native thiol/total thiol values. Ferroxidase activity was higher in insulin-resistant than in non-insulin-resistant women with obesity and higher in the total women with obesity group than in the overweight subjects (p<0.001, and p=0.014, respectively). IMA was lower in the insulin-resistant group than in the non-insulin-resistant group and overweight groups (p=0.011, and p=0.042, respectively).ConclusionsThe significantly greater increase in ferroxidase activity in insulin-resistant subjects with obesity may reflect its role as a positive acute phase protein. These findings may be related to the pathogenesis of the disease. Changes in oxidative status occur in women with obesity, and partially in overweight subjects. The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron.
Highlights
Obesity is a multifactorial and complex disease resulting from the interaction of genetic and environmental factors and is an important and priority health problem worldwide
The significantly greater increase in ferroxidase activity in insulin-resistant subjects with obesity may reflect its role as a positive acute phase protein
The ferroxidase activity of ceruloplasmin plays a crucial role in iron homeostasis and lowers oxidative stress by reducing the detrimental effects of iron
Summary
Obesity is a multifactorial and complex disease resulting from the interaction of genetic and environmental factors and is an important and priority health problem worldwide. Obesity is a chronic disease as well as a risk factor for the development of cardiovascular diseases, insulin resistance, diabetes, non-alcoholic fatty liver disease and cancer [1, 2]. High ROS levels can be seen in diabetic patients, and decreased insulin reactivity can be ameliorated by antioxidants, such as N-acetylcysteine (NAC). Albumin is the main plasma protein and plays various roles. It has antioxidant properties and is the major source of thiol in plasma. Thiol levels may be related to obesity, with low levels capable of facilitating the development of the disease [3]
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