Abstract
Abstract Objectives This article aims to explain the altered oxidative status and thiol/disulfide homeostasis before and after surgery in children with congenital heart disease (CHD). Methods Blood samples were taken from the patients (n=50) before the operation (baseline), at the 1st hour, and at the 24th hour after the operation. Thiol-disulfide levels, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), ceruloplasmin, albumin, ischemia-modified albumin (IMA), and prolidase activities of all samples were measured. Pre-operative oxygen saturation (SaO2) values and neutrophil/lymphocyte ratios (NLR) were also measured. Results Before the operation, TOS, OSI, MPO, ceruloplasmin, IMA, NRL, and disulfide levels were higher in the cyanotic group than in the acyanotic group. When the indicated three different time points were compared, the TOS, OSI levels, and MPO activities of the 24th hour were significantly lower than the baseline and 1st hour. In comparison, ceruloplasmin levels of 1st hour were significantly higher than of the baseline and 24th hour. Native thiol and total thiol levels in the baseline group were significantly lower than in the 1st and 24th hours. Disulfide levels of the 24th hour were significantly lower than of the baseline. Conclusions The operation leads to changes in the thiol-disulfide balance and oxidant status in CHD.
Highlights
Congenital heart disease (CHD) includes hereditary structural or functional anomalies in the cardiovascular system that can be identified at birth or later
Blood samples taken from the patients at three different time points were divided into groups and thiol-disulfide homeostasis, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), ceruloplasmin activities, albumin level, ischemia modified albumin (IMA) level, and prolidase activities were studied in all groups with a fully automated system (Siemens Advia 1800, Erlangen, Germany)
neutrophil/ lymphocyte ratios (NLR), neutrophil/lymphocyte ratio; TAS, total antioxidant status; TOS, total oxidant status; OSI, oxidative stress index. r and p are correlation coefficient and significance values. aSignificant compared among groups p< . . bSignificant compared among groups p
Summary
Congenital heart disease (CHD) includes hereditary structural or functional anomalies in the cardiovascular system that can be identified at birth or later. CHD covers more than one problem that affects the healthy function of the heart. Stress that occurs during or after surgery for CHD is one of these problems and triggers biochemical reactions [2]. In open-heart surgery, children require more precision and care than adults. There are a few studies on the oxidative stress state of children after cardiac surgery, there are no studies on thiol/disulfide equilibrium [4]. Studies investigating surgical outcomes in children with CHD have shown that pre-operative data (parameters such as age, body surface area, oxygen saturation, neutrophil ratio, leukocyte count, CRP, albumin level) influence clinical outcomes [5]
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