Abstract
Four unprecedented sulfur-containing cytochalasans, thiocytochalasins A−D (1−4), were isolated from an endophytic fungus Phoma multirostrata XJ-2-1. Thiocytochalasins A (1) and B (2) feature a novel 5/6/14/5 tetracyclic scaffold, which are the first examples of cytochalasan containing a thiophene moiety. Thiocytochalasins C (3) and D (4) are epimeric cytochalasan homodimers formed via a thioether bridge. Their structures with absolute configurations were established by detailed analysis of the HRESIMS, NMR, and X-ray crystallography. The plausible biogenetic pathway of 1−4 was postulated. Compounds 3 and 4 exhibited significant cytotoxicity against CT26 cells with IC50 values of 0.85 and 0.76 µmol/L, respectively.
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