Abstract
Thioacetamide toxicity in dogs has been studied. A dose of 25 mg/kg on alternate days will produce hepatic necrosis usually of the portal type, within twenty to thirty days. Six of the nine animals receiving this dose died in the stage of necrosis. The other three survived three to four months and developed hypertrophic cirrhosis with portal hypertension and ascites.Three dogs received 500 mg of thioacetamide twice a week. One died on the thirty-second day. The other two survived five and six months and developed atrophic cirrhosis of the Laennec type with abundant ascites. It is suggested that these animals have exhibited the phenomenon of Toxialepsy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
