Abstract
Chromatographic systems are described which are suitable for the examination of procaine penicillin G preparations which may contain, in addition to procaine and penicillin G, the degradation products p-aminobenzoic acid, ethyl p-aminobenzoate, benzylpenicilloic acid, and benzylpenillic acid. Further decomposition of penicillin G occurs when alcoholic solutions are used for spotting the chromtograms, the corresponding alkyl α-D-penicilloate being formed, whereas only penicillin G was detected when freshly prepared aqueous solutions were used. However, in aged aqueous solutions the rate of decomposition of penicllin G increased markedly and two new spots, due to benzylpenicilloic acid and benzylpenillic acid, were detected on the chromatogram.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
