Abstract
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflammatory drugs (NSAIDs), which act as selective or non-selective COX inhibitors. Almost all of them present a number of unwanted, often serious, side effects as a consequence of interference with the arachidonic acid cascade. In search for new drugs to avoid side effects, while maintaining high potency over inflammation, scientists turned their interest to the synthesis of dual COX/LOX inhibitors, which could provide numerous therapeutic advantages in terms of anti-inflammatory activity, improved gastric protection and safer cardiovascular profile compared to conventional NSAIDs. Τhiazole and thiazolidinone moieties can be found in numerous biologically active compounds of natural origin, as well as synthetic molecules that possess a wide range of pharmacological activities. This review focuses on the biological activity of several thiazole and thiazolidinone derivatives as COX-1/COX-2 and LOX inhibitors.
Highlights
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc
This review focuses on the biological activity of several thiazole and thiazolidinone derivatives found using mainly Google Scholar, Scopus and SciFinder
The same good activity resulted from a combination of thiazole with celecoxib, as well as phenyl substituted fused thiazole derivatives
Summary
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Thebecause chemistry of thiazolidinones drawn other hand, are ofthis thiazolidine, a saturated form ofisscientific thiazole, structure in a variety of synthetic compounds with a broad spectrum of biological activities, interest through group the years because2,this particular ring system is the core structure in a variety of with a carbonyl at position. 5. The chemistry of thiazolidinones has drawn scientific such as antimycobacterial [41,42], antifungal [43,44,45,46], anti-cancer anticonvulsant [51,52,53], synthetic compounds with a broad spectrum of ring biological activities, such as antimycobacterial interest through the years because this particular system is the[47,48,49,50], core structure in a variety of anti-edematous [54], [43,44,45,46], antidiarrheal anti-HIV [56,57],activities, anti-platelet-activating factor [58],. Thiazoles as COX/LOX Inhibitors et as al.COX/LOX [71] reported the synthesis of a series of 5,6-diarylimidazo[2.1-b]thiazole derivatives
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